Irresistible Spicy Southern Chicken Spaghetti Casserole

Name: Irresistible Spicy Southern Chicken Spaghetti Casserole
Prep time: 20 min
Cook time: 30 min
Total time: 50 min
Yield: 6 servings
Ingredients: 2 cups cooked spaghetti; 2 cups cooked chicken, shredded; 1 can (14.5 oz) diced tomatoes; 1 can (10 oz) cream of mushroom soup; 1 cup shredded cheddar cheese; 1/2 cup salsa; 1 tablespoon olive oil; 1 teaspoon garlic powder; 1 teaspoon onion powder; 1 teaspoon cayenne pepper; Salt and pepper to taste

Highlighted under: Comfort Food

This flavorful Southern Chicken Spaghetti Casserole combines tender chicken, a rich and zesty sauce, and al dente pasta for a comforting dish that packs a punch! Bursting with bold spices, it's an easy and satisfying meal the whole family will love, perfect for cozy nights or potluck gatherings.

Created by

Isla Turner

Last updated on 2025-11-23T07:51:28.674Z

This dish brings together the flavors of the South in a simple and delicious casserole format. It's perfect for a family dinner or a gathering with friends!

The Essence of Southern Cooking

Southern cooking is known for its rich and robust flavors, often featuring a delightful blend of spices that create comfort food at its best. Dishes like our Spicy Southern Chicken Spaghetti Casserole encapsulate these principles by stealing the spotlight with hearty ingredients like tender chicken, savory sauces, and al dente pasta. The unique combination of these elements brings warmth and satisfaction to the table, making it a beloved meal in many households.

Spices play a critical role in Southern dishes, and in our casserole, the kick of cayenne pepper harmonizes beautifully with the creaminess of the mushroom soup. This balance not only enhances the flavor but also offers a delightful warmth that resonates through each bite. It's this commitment to flavor that makes Southern dishes stand out and become lifelong favorites.

Perfect for Any Occasion

One of the best things about the Spicy Southern Chicken Spaghetti Casserole is its versatility. Whether you're planning a family dinner, a cozy night in, or even a potluck gathering with friends, this dish will impress your guests. Its hearty nature and vibrant flavors mean it can easily serve as the main attraction on any dining table, and it pairs wonderfully with a simple side salad or garlic bread for a complete meal.

Moreover, this casserole is not just tantalizing to the taste buds; it also promotes a sense of togetherness. Preparing and sharing a meal like this brings family and friends closer, making mealtime a wonderful opportunity to create lasting memories. Consider it your go-to dish for celebrations, casual get-togethers, or whenever you need to please a crowd.

Quick and Easy Meal Prep

In today's fast-paced world, preparing a delicious meal can sometimes feel like a daunting task. That's where our Spicy Southern Chicken Spaghetti Casserole shines. With simple and readily available ingredients, this recipe comes together quickly, allowing you to savor the cooking process rather than feeling rushed. In under an hour, you can have a delectable meal ready to go from oven to table.

Not only is this dish quick to prepare, it's also great for meal prepping. You can easily make a larger batch, freeze portions, and enjoy a home-cooked meal anytime throughout the week. Reheating is effortless, and it tastes just as good as when it was freshly prepared. This means one day of cooking can lead to several days of delightful dining.

Ingredients

For the Casserole

2 cups cooked spaghetti
2 cups cooked chicken, shredded
1 can (14.5 oz) diced tomatoes
1 can (10 oz) cream of mushroom soup
1 cup shredded cheddar cheese
1/2 cup salsa
1 tablespoon olive oil
1 teaspoon garlic powder
1 teaspoon onion powder
1 teaspoon cayenne pepper
Salt and pepper to taste

Mix all ingredients well in a bowl before combining them in your casserole dish.

Instructions

Preheat the Oven

Preheat your oven to 350°F (175°C).

Combine Ingredients

In a large mixing bowl, combine cooked spaghetti, shredded chicken, diced tomatoes, cream of mushroom soup, cheddar cheese, salsa, olive oil, garlic powder, onion powder, cayenne pepper, and season with salt and pepper. Mix until well combined.

Transfer to Casserole Dish

Pour the mixture into a greased 9x13 inch casserole dish and spread it evenly.

Bake

Cover the dish with aluminum foil and bake in the preheated oven for 25 minutes. Remove the foil and bake for an additional 5-10 minutes, until the cheese is bubbly and golden.

Serve

Let it cool for a few minutes before serving. Enjoy!

This casserole is best served hot and can be garnished with fresh herbs if desired.

Storage and Reheating Tips

After enjoying your Spicy Southern Chicken Spaghetti Casserole, store any leftovers in an airtight container in the refrigerator. It will keep well for about 3 to 4 days, giving you plenty of time to savor it again. For longer-term storage, consider freezing the casserole before baking. Wrap it tightly in aluminum foil or plastic wrap, then store it in the freezer for up to 2 months. When you’re ready to enjoy it, simply thaw in the refrigerator overnight before baking.

When reheating, you can do so in the oven or microwave. If using the oven, preheat to 350°F (175°C) and heat for approximately 20-25 minutes, or until thoroughly warmed. In the microwave, place individual portions on a microwave-safe plate and heat on high in 1-minute intervals until heated through. This way, you can enjoy leftovers without sacrificing flavor or texture.

Customization Ideas

While our Spicy Southern Chicken Spaghetti Casserole is delicious as is, feel free to add your own twist! You can incorporate additional veggies such as bell peppers, zucchini, or spinach for extra nutrition and color. These additions will not only enhance the visual appeal of the dish but will also provide added texture and flavor!

Another idea is to experiment with different cheese varieties or spices. Try using pepper jack cheese for an extra kick or an Italian blend for a twist on flavor. You could even adjust the amount of salsa based on your spice tolerance. The beauty of casseroles is their flexibility, allowing you to tailor them to your specific preferences and dietary needs.

Pairing Suggestions

To take your Spicy Southern Chicken Spaghetti Casserole to the next level, consider pairing it with complementary sides. A fresh garden salad dressed with lemon vinaigrette can provide a nice contrast to the richness of the casserole. Additionally, cornbread or a warm garlic bread roll would make a delightful accompaniment, ensuring you have something to soak up those delicious flavors.

For beverage options, sweet tea is a classic Southern choice that pairs wonderfully with this meal. Alternatively, a chilled white wine or sparkling water with a slice of lemon can elevate your dining experience, making it feel even more special. No matter how you choose to pair it, this dish promises to shine at every table.

Questions About Recipes

→ Can I use a different type of pasta?

Yes, feel free to use any pasta shape you like!

→ Can this be made ahead of time?

Absolutely! Assemble the casserole and store it in the refrigerator for up to a day before baking.